2. Signaling Pathways
  3. Anti-infection
  4. Reverse Transcriptase

Reverse Transcriptase

Reverse Transcriptase

Related Products

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Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.

Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.

Reverse Transcriptase Related Products (225):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14920
    Dexelvucitabine
    		Inhibitor 99.52%
    Dexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent.
    Dexelvucitabine
  • HY-B0249S
    Didanosine-d2
    		Inhibitor
    Didanosine-d2 is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
    Didanosine-d<sub>2</sub>
  • HY-142073
    (+)-Dihydrocalanolide A
    		Inhibitor
    (+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally active nonnucleoside inhibitor of Reverse Transcriptase. (+)-Dihydrocalanolide A can be used to HIV infection research.
    (+)-Dihydrocalanolide A
  • HY-W540188
    Calcium mesoxalate
    		Inhibitor
    Calcium mesoxalate blocks HIV-1 RT (IC50: 2.2 μM).
    Calcium mesoxalate
  • HY-19509R
    IQP-0528 (Standard)
    		Inhibitor
    IQP-0528 (Standard) is the analytical standard of IQP-0528. This product is intended for research and analytical applications. IQP-0528 is a highly potent nonnucleoside reverse transcriptase inhibitor (NNRTI). IQP-0528 shows nanomolar activity against both HIV-1 and HIV-2, with an HIV-1 EC50 of 0.2 nM and an HIV-2 EC50 of 100 nM.
    IQP-0528 (Standard)
  • HY-14266A
    Dapivirine hydrochloride
    		Inhibitor
    Dapivirine hydrochloride is a non-nucleoside reverse transcriptase inhibitor with antitumor activity. Dapivirine hydrochloride attenuates the proliferation of glioblastoma cells and induces apoptosis. Dapivirine hydrochloride modulates autophagy and activates Akt, Bad, and SAPK/JNK signaling pathways. Dapivirine hydrochloride has shown inhibitory effects on glioma cell growth both in vitro and in vivo. Dapivirine hydrochloride is also a promising drug candidate for topical microbial agents for the prevention of sexual transmission of HIV-1.
    Dapivirine hydrochloride
  • HY-90005R
    Etravirine (Standard)
    		Inhibitor
    Etravirine (Standard) is the analytical standard of Etravirine. This product is intended for research and analytical applications. Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
    Etravirine (Standard)
  • HY-163110
    NNRT-IN-2
    		Inhibitor
    NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics.
    NNRT-IN-2
  • HY-105216
    L 697661
    		Inhibitor
    L 697661 is an orally active HIV-1 reverse transcriptase inhibitor.
    L 697661
  • HY-162461
    HIV-1 inhibitor-66
    		Inhibitor
    HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC50 of 40 nM.
    HIV-1 inhibitor-66
  • HY-151933
    HIV-1 inhibitor-49
    		Inhibitor
    HIV-1 inhibitor-49 is an orally active HIV-1 inhibitor, is a HEPT analog. HIV-1 inhibitor-49 possesses great pharmacokinetics profiles and potent non-nucleoside reverse transcriptase inhibitory activity (IC50=30 nM). HIV-1 inhibitor-49 exerts potential safety without acute toxicity in mouse model.
    HIV-1 inhibitor-49
  • HY-10572B
    (Rac)-Efavirenz
    		Inhibitor
    (Rac)-Efavirenz is the isomer of Efavirenz (HY-10572). Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
    (Rac)-Efavirenz
  • HY-117725
    S-2720
    		Inhibitor
    S-2720 is a potent inhibitor of both immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) and HIV-1 replication. The binding sites of S-2720 and the nonnucleoside compounds overlap. The small pocket in the p66 subunit-BI-RG-587 (HY-10570) complex is most likely the target of S-2720. S-2720 is a quinoxaline derivative, which is promising for research of HIV-1 infection.
    S-2720
  • HY-B0250S1
    Lamivudine-13C,15N2,d2
    		Inhibitor
    Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase.
    Lamivudine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>,d<sub>2</sub>
  • HY-126900
    HI-253
    		Inhibitor
    HI-253 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase that has demonstrated greater activity than multiple anti-HIV compounds against both resistant and sensitive HIV-1 strains.
    HI-253
  • HY-P11158
    Gymnin
    		Inhibitor
    Gymnin is a defensin-like antifungal peptide. Gymnin has significant antifungal activities against phytopathogenic and mycotoxigenic fungi. Gymnin inhibits HIV-1 reverse transcriptase with an IC50 of 200 μM and the proliferation of tumor cells. Gymnin has a weak mitogenic activity toward murine splenocytes. Gymnin can be used for plant disease treatments research.
    Gymnin
  • HY-138561
    EFdA-TP
    		Inhibitor
    EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms.
    EFdA-TP
  • HY-118632
    BILR 355
    		Inhibitor
    BILR 355 is a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI). BILR 355 is highly specific toward HIV-1 reverse transcriptase (RT). BILR 355 can be used for HIV infections research.
    BILR 355
  • HY-106155
    Amdoxovir
    		Inhibitor
    Amdoxovir (DAPD) is an orally active nucleoside reverse transcriptase inhibitor. Amdoxovir is active against wild-type and NRTl-resistant viruses. Amdoxovir is the prodrug of dioxolane guanosine. Amdoxovir can be used for research of HIV/AIDS.
    Amdoxovir
  • HY-W765997
    Didanosine-13C2,15N
    Didanosine-13C2,15N (2',3'-Dideoxyinosine-13C2,15N; ddI-13C2,15N) is the 13C- and 15N-labeled labeled Didanosine (HY-B0249). Didanosine (2',3'-Dideoxyinosine; ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV.
    Didanosine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N